![]() Chef Mauro’s team will include a scientific gardener from Mirazur’s garden who will spend time with local producers and farmers, exchanging Mirazur’s eco-conscious gardening techniques and learning new skills from the Mexican culture. Mirazur Beyond Borders will not only provide a unique and fine dining experience for Montage Los Cabos’ guests but it will also further both the restaurant and the resort’s commitment to sustainability. Photo used with permission by Montage Los Cabos “The residency at Montage Los Cabos is not only a unique and fine dining experience, it will also serve as an opportunity for myself and our team to immerse in the local culture, and better understand Mexican soil, land, and the natural environment,” said Chef Mauro. ![]() Chef Mauro and his team will use their time in the destination to study and experiment Mexican products, flavors, and soils to craft this unique culinary journey and spark creativity for the reopening in France. Mirazur Beyond Borders will be a once-in-a-lifetime experience that celebrates the richness of Mexican culture and terroir, and the bountiful produce found in Baja. Montage Los Cabos, Photo used with permission by Montage Los Cabos While Mirazur renews the Heart of the Restaurant in Menton, France with a complete renovation of the kitchen, Chef Mauro will take up residency at Montage Los Cabos, making the resort the only place in the world to experience Mirazur ́s holistic approach to fine cuisine from February 9-18. Montage Los Cabos, a luxury resort nestled in an idyllic cove along swimmable Santa Maria Bay, and Mirazur restaurant, from Chef Mauro Colagreco, in Menton, France – crowned the #1 restaurant in the world by The World’s 50 Best Restaurants in 2019, are pleased to announce ‘Mirazur Beyond Borders’ at Montage Los Cabos, an exclusive dinner series.
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![]() Although initiation of homologous recombination is required for the deletions observed in blm mutants, the molecular mechanisms responsible for deletion formation remain unknown. In its absence, DSB repair frequently proceeds through non-conservative, deletion-prone repair mechanisms. DmBlm is required for accurate homologous recombination (HR) repair of site-specific DNA double-strand breaks (DSBs) and for prevention of mitotic crossovers. Flies lacking DmBlm phenocopy many of the characteristics of human Bloom syndrome, including reduced fertility and increased mitotic sister chromatid exchanges. The mus309 gene encodes the Drosophila melanogaster BLM ortholog DmBlm. Because these types of mutations are hypothesized to be driving forces in the development and progression of cancer in Bloom syndrome patients, understanding their origin is important. The cause of this is poorly understood, but it may be related to the increased number of chromosome aberrations and translocations that are observed in BLM mutant cells. Ĭells with defective BLM also have a heightened mutation frequency that is partially independent of the increase in sister chromatid exchanges. Cells derived from Bloom syndrome patients and Blm hypomorphic mice exhibit greatly elevated genome instability, including a dramatically increased frequency of sister chromatid exchanges. It is caused by mutations in the BLM gene, a member of the RecQ family of DNA helicases. In addition, since loss of BLM significantly affects lifespan and tumorigenesis, the data provide a link between error-prone end joining, genome rearrangements, and tumor formation in a model metazoan.īloom syndrome is a rare, autosomal recessive disorder whose most striking characteristic is a predisposition to all types of cancers (reviewed in ). These results suggest that Drosophila BLM suppresses error-prone alternative end-joining repair of DNA double-strand breaks that can result in genome instability and tumor formation during aging. Adult blm mutants also display reduced lifespan and ligase 4-independent enhanced tumorigenesis in mitotically active tissues. Although in normal flies most genome rearrangements occur through DNA ligase 4-dependent classical end joining, most rearrangements that accumulate during aging in blm mutants do not require DNA ligase 4, suggesting the influence of an alternative end-joining mechanism. Our data show that Drosophila lacking BLM have an elevated frequency of spontaneous genome rearrangements that increases with age. To address this, we used a lacZ reporter system in wild-type and several mutant strains of Drosophila melanogaster to analyze mechanisms of mutagenesis throughout their lifespan. In addition, the effect of aging on spontaneous mutagenesis in blm mutants has not been characterized. Humans and mice with blm mutations have increased frequencies of spontaneous mutagenesis, but the molecular basis of this increase is not well understood. ![]() Mutations in BLM cause Bloom syndrome, a rare disorder associated with cancer predisposition and premature aging. The BLM DNA helicase plays a vital role in maintaining genome stability. ![]() There has been a feeling of shock andīut US prosecutors have said the charges against herĪre accusations and she is innocent until proven guilty. ![]() Over four million followers on Instagram. Montrage is an influential musician in Ghana with Prosecutors have also alleged she swindled In one instance, she is alleged to have extortedĪbout $89,000 through 82 wire transfers after sending the victim a fake Victims into believing they were in a romantic relationship - and then exploited Sent a series of emails, text messages and social media messages to trick Targeted older American men, women and businesses. Montrage, popularly known as Hajia4Reall, and her alleged criminal enterprise are accused of engaging in fraud including romance scams between 20. Maximum sentence of 10 years in jail, and conspiracy to receive stolen money, She was also charged with receipt of stolen money, which carries a Prosecutors said she was charged with conspiracy to commit and committing wire fraud and money laundering, each of which carries a maximum sentence of 20 years She appeared before a judge on Monday but is still inĬustody until all bail conditions are met. Musician and influencer Mona Faiz Montrage, who was extradited to the US from the UK over an alleged $2m (£1.6m) romance scam, has pleaded not Hajia4Reall/Instagram Copyright: Hajia4Reall/Instagram Montrage is an influential musician in Ghana with over four million followers on Instagram Image caption: Montrage is an influential musician in Ghana with over four million followers on Instagram Inspiration to bring relevant products to our fans across South Africa,” KFC was “We will continue to use South African food trends as The South African heritage and culture to develop local innovative products in It said that for over 50 years, the chain had been inspired by Of an internal product development process”. Is a famous South African meal and the limited-edition KFC Sphatlho is a result Mr Malepe is also said to have taken to social media recently to condemn the fast-food chain for allegedly taking his idea which he said he developed four years ago.īut KFC has refuted the claims in a statement to South African media, saying it was “no Kota” was stolen while looking for a partnership with the chain. Mr Malepe told a local publication that his idea for a “Streetwise Loaf of bread, wrapped and eaten on the go. ![]() Is a big sandwich with multiple ingredients stuffed into a quarter Idea of a chicken kota that the fast food chain is launching. Romeo Malepe accuses KFC of appropriating his Getty Images Copyright: Getty Images Sphatlho or Kota is a big sandwich with multiple ingredients stuffed into a quarter loaf of bread Image caption: Sphatlho or Kota is a big sandwich with multiple ingredients stuffed into a quarter loaf of breadįast food giant KFC has dismissed claims by a South AfricanĮntrepreneur accusing the company of stealing his idea of a local dish known as kota, local My dream is for more girls to stay in school,” Zamana said after receiving the award on Tuesday night in London’s Theatre Royal Drury Lane.įollowing the ceremony, Zamana will later on Wednesday meet King Charles III during a reception at Buckingham Palace to celebrate the winners’ achievements.įounded by the King, Prince’s Trust International supports young people across 18 countries through employment, education and enterprise programmes. Every girl in my community has a dream for her future, just like girls all over the world. Through her “Allow Me To Study” campaign, Zamana focuses on helping schoolgirls and their parents understand the importance of completing their education. The annual Prince’s Trust Awards recognise young people who have succeeded against the odds, improved their chances in life and had a positive impact on their local community.Īward winner Zamana was recognised after launching her own campaign to support and encourage girls to stay in school in Tanzania. Prince’s Trust International Copyright: Prince’s Trust International Zamana was recognised for her campaign to help Tanzanian girls stay in school Image caption: Zamana was recognised for her campaign to help Tanzanian girls stay in schoolĪ Tanzanian teen has won the Amal Clooney Women’s Empowerment Award in London for her efforts to support girls' education. |